When estranged brothers Adam and Clint attempt to reconnect over a week-long hunting trip in remote British Columbia, they find the tables turned by a mysterious presence lurking in the forest. Convinced that they are now besieged by a supernatural presence, the siblings begrudgingly agree on only one thing: they will have to put aside their differences and work together if they plan on making it out these dark woods alive.

In the year 2056 - the not so distant future - an epidemic of organ failures devastates the planet. Out of the tragedy, a savior emerges: GeneCo, a biotech company that offers organ transplants, for a price. Those who miss their payments are scheduled for repossession and hunted by villainous Repo Men. In a world where surgery addicts are hooked on painkilling drugs and murder is sanctioned by law, a sheltered young girl searches for the cure to her own rare disease as well as information about her family's mysterious history. After being sucked into the haunting world of GeneCo, she is unable to turn back, as all of her questions will be answered at the wildly anticipated spectacular event: The Genetic Opera.